Many women with PCOS realize that they have significant hormonal dysfunctions,
manifesting in many ways, including menstrual irregularities, thyroid problems, insulin resistance and glucose dysregulation, weight loss resistance, sleep problems, and infertility.
Among the many hormones which can be dysfunctional isprogesterone. In fact, women with PCOS do have serious progesterone “issues.” The concerns involving progesterone can result in an increased risk for miscarriages, pregnancy complications and preterm delivery, irregular cycles, PMS and mood swings, and significantly elevated risk for uterine lining (endometrial) overgrowth (hyperplasia) and uterine cancer!!
The elevated uterine (endometrial) cancer risk arises from infrequent and irregular ovulation and from progesterone receptor resistance. The continuous estrogen production results in an imbalanced situation in which there is chronic, unopposed exposure of the uterine lining (endometrium) to estrogen, without the balancing effects of progesterone. The progesterone receptor resistance issue compounds the problem by not allowing the progesterone which is produced to have the desired effects upon the progesterone receptors throughout the body. And of course, by not properly impacting the receptors on the uterine lining, the effects of estrogen dominate; increase the cancer risk, with the result being frank endometrial cancer developing, in some cases. Shockingly, such cancers can occur at surprisingly young ages!
Progesterone receptors reside throughout the female body. Among the other progesterone receptors which have received much attention are those in the breasts. In fact, there is now much written that in the event of radiation exposure, both large and small, progesterone can possibly affect certain breast stem cells, now known as cancer stem cells, stimulating them to develop into florid cancer cells.
http://pcosdiva.com/2015/09/pcos-treatment-progesterone-cream/?inf_contact_key=acf08833e8e179febaafbbe34eeefb38eafc5cff1cadaef454827cc53678fd3e
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